Objective: Malignant tumors greatly endanger and affect the quality of human life. Among antitumor biotherapy strategies......

The amyloid-β (Aβ) oligomer, rather than the Aβ monomer, is considered to be the primary initiator of Alzheimer\'s ......

Castration of male animals is a common practice in the meat industry aimed at reducing aggressive behavior, preventing u......

Dengue fever,caused by dengue viruses (DENVs),is a widespread mosquito-borne zoonotic disease;however,there is no availa......

White spot syndrome virus (WSSV) is a virulent pathogen causing high mortality and large economic loss in cultured shrim......

Disorganized Muscle family member (Dim: 1) belongs to immunoglobulin superfamily,and is a structural protein localized t......

Aim: To evaluate the protective efficacy of a DNA vaccine encoding T.gondii ROP5 and GRA15 antigens.Methods: We construc......

Lymphocystis disease,caused by the lymphocystis disease virus (LCDV),is a significant worldwide problem in fish industry......

Toxoplasma gondii 10 kDa excretory-secretory antigen(TgESA10)is involved in the early stages of host invasion....

This study aimed to determine the changes of cytokines,specific serum IgG and several parameters in chickens vaccinated ......

Chimeric DNA vaccines co-expressing Eimeria acervulina macrophage migration inhibitory factor(E.MIF)and chicken IL-2(IL-......

Chimeric DNA vaccines encoding Eimeria tenella(E.tenella)surface antigen 5401 were constructed and their efficacies agai......

Avian coccidiosis is mostly caused by mixed infection of several Eimeria species under natural conditions and immunity t......

The search for effective vaccines against chicken coccidiosis remains a challenge because of the complex organisms with ......

Toxoplasma gondii is one of the most prevalent intracellular parasites and is threatening the health of both humans and ......

In the present study,we constructed a DNA vaccine expressing T.gondii CDPK3 (TgCDPK3) and evaluated its protective effic......

Plasmids expressing macrophage migration inhibitory factor (MIF) of Trichinella spiralis (TsMIF),multi-cystatin-like dom......

Background : Endogenous antigen encoded by conventional naked DNA was processed by antigen-presenting cells (APCs) and o......

Objective: we have investigated the cellular and humoral immune responses in ex vivo and immune protection in vivo of im......

Lysosome-associated membrane protein (LAMP) can target and bind to endosome/lysosome, one of the most important componen......

Toxoplasma gondii,an obligatory intracellular parasite,which can infect all warm-blooded animals including humans.Cytoki......

In addition to vector control and malaria chemotherapy, immunological intervention will be needed to stop the resurgence......

Several strategies have been pursued to develop cancer selective therapies that selectively act on and kill cancer cell-......

Dengue virus (DV) has four distinct serotypes.A proper dengue vaccine should be tetravalent and induce equivalent and du......

Background Toxoplasma gondii(T.gondii)is an obligate intracellular protozoan parasite that affects a large variety of wa......

Toxoplasma gondii is an intracellular obligate parasitic protozoon that can cause zoonotic infection in humans.DNA vacci......

Objective To evaluate the effect of co-expression DNA vaccine containing GAD65 fragment and IL-10 gene in preventing you......

We have engineered a DNA vaccine that expresses extracelluar region of murine VEGFR-2 (FLK265-2 493) and 3 copies of C3d......

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The situation of tuberculosis (TB) is very severe in China.New therapeutic agents or regimens to treat TB are urgently n......

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Antigen-85A (Ag85A) is one of the major proteins secreted by Mycobacterium tuberculosis.Many studies on animal models ha......

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　　Co-expression of Trichinella spiralis macrophage migration inhibitory factor (TsMIF) with T.spiralis cystatin-like d......

　　Mycobacterium tuberculosis (M tuberculosis) has a penetrance of its host population.About one-third of the human pop......

　　Tuberculosis (TB), caused by Mycobacterium tuberculosis (M tuberculosis), is a worldwide public health problem and h......

目的：观察一种结构新颖的HCV融合抗原DNA疫苗在BALB/c小鼠的免疫效果，探讨其用于防治丙型肝炎的可行性。方法：用重叠延伸PCR拼接编码......

扩增了奶牛乳腺炎金黄色葡萄球菌ClfA基因,并将其克隆至真核表达载体pVAX1启动子下游,构建成真核表达质粒,通过体外细胞转染试验,......

目的探讨DNA疫苗p(Aβ3-10)10-mIL-4免疫对APP/PS1转基因小鼠行为学及脑内β淀粉样蛋白沉积的影响。方法构建表达重复10次的β淀粉......

In order to investigate immunogenicity in the induction of humoral and cellular immune responses, severe acute respirato......

Vaccination with DNA encoding Dermatophagoides pteronyssinus group 2 (Der p 2) allergen previously showed its effects of......

Collagen-induced arthritis (CIA) is an animal model, which closely resembles human rheumatoid arthritis (RA) in pathogen......

Two Schistosoma japonicum vaccine candidate antigens Sj 31 and Sj 32, which have shown particular promise to induce prot......

This study was to prepare the chitosan-pDer p 2 nanoparticles and to investigate the effect of chitosan-DNA nanoparticle......

AIM: To seek for an effective method to improve the immuneresponses induced by DNA vaccine expressing HBV surfaceantigen......

AIM: To construct a DNA vaccine encoding human alphafetoprotein (hAFP)/heat shock protein 70 (HSP70), and to study its a......

AIM: To construct a DNA vaccine against extracellular domains 1-3 of fetal liver kinase-1 (flk-1), and to investigate it......

AIM: To construct the plasmid pcHEV23 containing fragments of HEV ORF2 and ORF3 chimeric gene and to assess its ability ......